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KMID : 1134120180210010087
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Journal of Breast Cancer
2018 Volume.21 No. 1 p.87 ~ p.90
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Identification of the Thioredoxin-Like 2 Autoantibody as a Specific Biomarker for Triple-Negative Breast Cancer
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Chung Jee-Min
Jung Yong-Sik
Kim Young-Pil
Song Jin-Sue
Kim So-Yeon
Kim Ji-Young
Kwon Mi-Ra
Yoon Jung-Hyun
Kim Myo-Deok
Lee Jun-Kyoung
Kang Joo-Seong
Kang Ho-Chul
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Abstract
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Triple-negative breast cancer (TNBC) has a higher risk of death within 5 years of being diagnosed than the other forms of breast cancer. It is the second leading cause of death due to cancer among women. Currently, however, no diagnostic blood-based biomarker exists to identify the early stages of TNBC. To address this point, we utilized a human protein microarray system to identify serum autoantibodies that showed different expression patterns between TNBC and normal serum samples, and identified five autoantibodies showing TNBC-specific expression. Among them, we selected the thioredoxin-like 2 (TXNL2) autoantibody and evaluated its diagnostic relevance by dot blot analysis with the recombinant TXNL2 protein. We demonstrated that the TXNL2 autoantibody showed 2- to 6-fold higher expression in TNBC samples than in normal samples suggesting that serum TXNL2 autoantibodies are potential biomarkers for TNBC.
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KEYWORD
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Autoantibodies, Biomarkers, Breast neoplasms, Protein array analysis
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